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  • Citation:

    Xu, W., Cao, S., He, X., Luo, Y., Guo, X., Yuan, Y., Huang, K. (2009). Safety assessment of Cry1Ab/Ac fusion protein. Food and Chemical Toxicology, 47(7), 1459-1465.

Publication type:

 peer-reviewed article

Comment:

Content type:
safety

Keyword:
food and feed safety, food/feed safety, Cry, Bt, Bacillus thuringiensis, GMO, Cry1Ab

Publication Year:

 2009

Authority:

 Research group

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 peer-reviewed articleLink to the document url.

  • Abstract:

    Cry1ab/ac gene was fused by both the cry1ab gene (GenBank Accession No. X54939) and the cry1ac gene (GenBank Accession No. Y09787), which was widely used in genetically modified (GM) rice, cotton, maize and so on. In order to support the safety assessment of CM food or feed products containing Cry1Ab/Ac protein, sufficient quantities of Cry1Ab/Ac protein were produced in Escherichia coli for in vitro evaluation and animal studies. The Cry1Ab/Ac protein does not possess the characteristics associated with food toxins or allergens, i.e., it has no sequence homology with any known allergens or toxins, and no N-glycosylation sites, can be rapidly degraded in gastric and intestinal fluids, and is devoid of adverse effects in mice by gavage at a high dose level of 5 g (Cry1Ab/Ac protein)/kg body weight. In conclusion, there is a reasonable certainty of no harm resulting from the inclusion of the Cry1Ab/Ac protein in human food or animal feed.