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Description:
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Southern blot analyses indicated the integration of the opAFP-GHc2 gene construct (EO-1alpha) at a single genomic locus. PCR and sequence analyses indicated that the construct had been reorganized. The insertion consists of the 3' segment (614 base pairs) of the ocean pout antifreeze promoter region (opAFP), the intact chinook salmon GH cDNA, the complete ocean pout antifreeze termination region and the first 1678 base pairs of the ocean pout antifreeze 5' region.
Sources:
Yaskowiak ES, Shears MA, Agarwal-Mawal A, Fletcher GL (2006) Characterization and multi-generational stability of the growth hormone transgene (EO-1α) responsible for enhanced growth rates in Atlantic Salmon. Transgenic Research 15: 465–480 Freedom of Information Summary (FOI) Original New Animal Drug Application (NADA 141-454): opAFP-GHc2 rDNA construct in EO-1α lineage Atlantic salmon (AquAdvantage Salmon) Date of Approval: November 19, 2015
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Links regarding to this GMO:
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BCH Record ID: 104725 http://bch.cbd.int/database/record.shtml?documentid=104725,
Scientific publication - Yaskowiak et al. (2006) https://link.springer.com/article/10.1007%2Fs11248-006-0020-5,
NADA 141-454 https://www.fda.gov/media/93801/download
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Transformation / Modification technique:
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microinjection
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